loading...| Preferred Name | Schwann cell | |
| Synonyms |
neurolemmocyte |
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| Definitions |
A glial cell that myelinates or ensheathes axons in the peripheral nervous system. A myelinating Schwann cell wraps around a single axon. Myelination occurs in larger diameter axons, while a process called ensheathment occurs on smaller diameter axons in which a single cell wraps around multiple small, unmyelinated axons separating them with a thin layer of cytoplasm. The structure formed is called a Remak bundle. |
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| ID |
http://purl.obolibrary.org/obo/CL_0002573 |
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| comment |
A myelinating Schwann cell wraps around a single axon. Myelination occurs in larger diameter axons, while a process called ensheathment occurs on smaller diameter axons in which a single cell wraps around multiple small, unmyelinated axons separating them with a thin layer of cytoplasm. The structure formed is called a Remak bundle. |
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| description |
This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies to only to some subtypes and species, and so should not be considered definitional. Schwann cells, also known as neurolemmocytes, are a type of glial cell located in the peripheral nervous system. These cells play a significant role in the healthy functioning of nerves by producing myelin, a fatty substance that forms a coating around nerve fibers. Myelin serves as an insulator and enhances the speed and efficiency of electrical nerve impulses; a single Schwann cell can myelinate a single axon. Myelination starts by the elongation and envelopment of the Schwann cell around the axon, followed by the synthesis and deposition of myelin layers. Some studies suggest that Schwann cells may regulate neuronal action potential, muscular contraction, and the sensitive response. While Schwann cells are most commonly known for the formation of the myelin sheath, some Schwann cells do not form myelin: Remak Schwann cells, a class of nonmyelinating Schwann cells, ensheath axons with smaller diameter, such as C fiber nociceptors in sciatic nerves and form Remak bundles. Schwann cells are found along both motor and sensory neurons and are crucial for the advancement and recovery of peripheral nerve injuries, due to their capacity to support nerve regeneration. In cases of nerve injury, Schwann cells play a vital role in recovery by initiating Wallerian degeneration, a process in which the part of the axon distal to the injury site degrades and is then cleared away. Following this, Schwann cells can guide the regrowth of the nerve, providing a conducive environment for axon regeneration. They remodel themselves into a regenerative phenotype, proliferate, and organize themselves into bands of Büngner that provide physical and chemical guidance for the regrowths of axons. This function of Schwann cells in the repair and regeneration of nervous system highlights their therapeutic potential in peripheral nerve injury treatments. |
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| contributor | ||
| creation_date |
2011-03-02T01:19:27Z |
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| database_cross_reference |
MESH:D012583 https://cellxgene.cziscience.com/cellguide/CL_0002573 BTO:0001220 CALOHA:TS-0898 |
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| definition |
A glial cell that myelinates or ensheathes axons in the peripheral nervous system. |
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| has_exact_synonym |
neurolemmocyte |
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| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas |
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| label |
Schwann cell |
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| preferred label |
Schwann cell |
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| prefixIRI |
CL:0002573 |
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| prefLabel |
Schwann cell |
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| RO_0002175 | ||
| subClassOf |