loading...| Preferred Name | macrophage | |
| Synonyms |
histiocyte |
|
| Definitions |
A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. |
|
| ID |
http://purl.obolibrary.org/obo/CL_0000235 |
|
| comment |
Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. |
|
| database_cross_reference |
CALOHA:TS-0587 BTO:0000801 SNOMEDCT:58986001 ZFA:0009141 NIFSTD:sao185843373 MESH:D008264 NCIt:C12558 FMA:63261 FMA:83585 |
|
| definition |
A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. |
|
| has_exact_synonym |
histiocyte |
|
| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim |
|
| label |
macrophage |
|
| located_in | ||
| preferred label |
macrophage |
|
| prefixIRI |
CL:0000235 |
|
| prefLabel |
macrophage |
|
| RO_0002175 | ||
| subClassOf |
http://purl.obolibrary.org/obo/CL_0000842 |