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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Spironolactone | |
| Synonyms |
|
|
| Definitions |
A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities.Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C840 |
|
| CAS_Registry |
52-01-7
|
|
| CHEBI_ID |
CHEBI:9241
|
|
| Chemical_Formula |
C24H32O4S
|
|
| code |
C840
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities.Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors.
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|
| Display_Name |
Spironolactone
|
|
| FDA_UNII_Code |
27O7W4T232
|
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Spironolactone
|
|
| Legacy Concept Name |
Spironolactone
|
|
| NCI_Drug_Dictionary_ID |
39444
|
|
| NSC Number |
150399
|
|
| PDQ_Closed_Trial_Search_ID |
39444
|
|
| PDQ_Open_Trial_Search_ID |
39444
|
|
| Preferred_Name |
Spironolactone
|
|
| prefixIRI |
NCIT:C840
|
|
| prefLabel |
Spironolactone
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0037982
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|
| subClassOf |
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