loading...| Preferred Name |
Tacrolimus Anhydrous |
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| Synonyms |
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| Definitions |
Anhydrous from of tacrolimus, a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C76066 |
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| CAS_Registry |
104987-11-3 |
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| CHEBI_ID |
CHEBI:61049 |
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| Chemical_Formula |
C44H69NO12 |
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| code |
C76066 |
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| Contributing_Source |
FDA |
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| definition |
Anhydrous from of tacrolimus, a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. |
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| FDA_UNII_Code |
Y5L2157C4J |
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| in_subset | ||
| label |
Tacrolimus Anhydrous |
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| Legacy Concept Name |
Anhydrous_Tacrolimus |
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| Preferred_Name |
Tacrolimus Anhydrous |
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| prefixIRI |
NCIT:C76066 |
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| prefLabel |
Tacrolimus Anhydrous |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0771204 |
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| subClassOf |