loading...| Preferred Name |
Calcineurin Inhibitor |
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| Synonyms |
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| Definitions |
Any agent that inhibits calcineurin (protein phosphatase 3; PPP3), a serine/threonine protein phosphatase dependent on calcium and calmodulin, with immunosuppressant activity. Inhibition of calcineurin prevents dephosphorylation of the transcription factor nuclear factor of activated T-cells, cytoplasmic (NFATc), which prevents its translocation to the nucleus and the subsequent induction of the expression of interleukin-2 (IL-2). This prevents IL-2-mediated proliferation and activation of T-cells, and T-lymphocyte-mediated immune responses. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C146638 |
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| code |
C146638 |
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| Contributing_Source |
CTRP |
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| definition |
Any agent that inhibits calcineurin (protein phosphatase 3; PPP3), a serine/threonine protein phosphatase dependent on calcium and calmodulin, with immunosuppressant activity. Inhibition of calcineurin prevents dephosphorylation of the transcription factor nuclear factor of activated T-cells, cytoplasmic (NFATc), which prevents its translocation to the nucleus and the subsequent induction of the expression of interleukin-2 (IL-2). This prevents IL-2-mediated proliferation and activation of T-cells, and T-lymphocyte-mediated immune responses. |
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| Display_Name |
Calcineurin Inhibitor |
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| Has_Target | ||
| in_subset | ||
| label |
Calcineurin Inhibitor |
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| Preferred_Name |
Calcineurin Inhibitor |
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| prefixIRI |
NCIT:C146638 |
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| prefLabel |
Calcineurin Inhibitor |
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| Semantic_Type |
Chemical Viewed Functionally |
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| UMLS_CUI |
C1562036 |
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| subClassOf |