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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Desipramine | |
| Synonyms |
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| Definitions |
An active metabolite of imipramine, a tertiary amine and a synthetic tricyclic derivative of the antidepressant. Desipramine enhances monoamine neurotransmission in certain areas of the brain by inhibiting the re-uptake of noradrenaline and serotonin at the noradrenergic and serotoninergic nerve endings, respectively. It also induces sedation through histamine 1 receptor blockage and hypotension through beta-adrenergic blockage. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C61700 |
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| CAS_Registry |
50-47-5
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| CHEBI_ID |
CHEBI:47781
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| Chemical_Formula |
C18H22N2
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| code |
C61700
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| Contributing_Source |
FDA
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|
| definition |
An active metabolite of imipramine, a tertiary amine and a synthetic tricyclic derivative of the antidepressant. Desipramine enhances monoamine neurotransmission in certain areas of the brain by inhibiting the re-uptake of noradrenaline and serotonin at the noradrenergic and serotoninergic nerve endings, respectively. It also induces sedation through histamine 1 receptor blockage and hypotension through beta-adrenergic blockage.
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| FDA_UNII_Code |
TG537D343B
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| Has_Salt_Form | ||
| in_subset | ||
| label |
Desipramine
|
|
| Legacy Concept Name |
Desipramine
|
|
| Preferred_Name |
Desipramine
|
|
| prefixIRI |
NCIT:C61700
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| prefLabel |
Desipramine
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0011685
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| subClassOf |
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