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Biological and Environmental Research Ontology
| Preferred Name | Glutathione | |
| Synonyms |
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|
| Definitions |
A tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids, and in the synthesis of leukotrienes. As a substrate for glutathione S-transferase, this agent reacts with a number of harmful chemical species, such as halides, epoxides and free radicals, to form harmless inactive products. In erythrocytes, these reactions prevent oxidative damage through the reduction of methemoglobin and peroxides. Glutathione is also involved in the formation and maintenance of disulfide bonds in proteins and in the transport of amino acids across cell membranes. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C523 |
|
| ALT_DEFINITION |
A substance found in plant and animal tissues that has many functions in a cell. These include activating certain enzymes and destroying toxic compounds and chemicals that contain oxygen.
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| CAS_Registry |
70-18-8
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| CHEBI_ID |
CHEBI:16856
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| Chemical_Formula |
C10H17N3O6S
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|
| code |
C523
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| Contributing_Source |
CTRP FDA
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|
| definition |
A tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids, and in the synthesis of leukotrienes. As a substrate for glutathione S-transferase, this agent reacts with a number of harmful chemical species, such as halides, epoxides and free radicals, to form harmless inactive products. In erythrocytes, these reactions prevent oxidative damage through the reduction of methemoglobin and peroxides. Glutathione is also involved in the formation and maintenance of disulfide bonds in proteins and in the transport of amino acids across cell membranes.
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| Display_Name |
Glutathione
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| FDA_UNII_Code |
GAN16C9B8O
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 |
|
| label |
Glutathione
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|
| Legacy Concept Name |
Glutathione
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|
| NCI_Drug_Dictionary_ID |
655232
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| NSC Number |
400639
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| PDQ_Closed_Trial_Search_ID |
655232
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|
| PDQ_Open_Trial_Search_ID |
655232
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|
| Preferred_Name |
Glutathione
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|
| prefixIRI |
NCIT:C523
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|
| prefLabel |
Glutathione
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C0017817
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| subClassOf |
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