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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Levetiracetam | |
| Synonyms |
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| Definitions |
A pyrrolidine with antiepileptic activity. The exact mechanism through which levetiracetam exerts its effects is unknown but does not involve inhibitory and excitatory neurotransmitter activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47581 |
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| Accepted_Therapeutic_Use_For |
Treating partial-onset seizures in patients with epilepsy.
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| ALT_DEFINITION |
A drug used to treat seizures (involuntary muscle movements) caused by epilepsy (a group of brain disorders). Keppra is being studied in the treatment of seizures in patients with cancer that has spread to the brain. It is a type of anticonvulsant.
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| CAS_Registry |
102767-28-2
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| CHEBI_ID |
CHEBI:6437
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| Chemical_Formula |
C8H14N2O2
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| code |
C47581
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| Contributing_Source |
FDA
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| definition |
A pyrrolidine with antiepileptic activity. The exact mechanism through which levetiracetam exerts its effects is unknown but does not involve inhibitory and excitatory neurotransmitter activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity.
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| FDA_UNII_Code |
44YRR34555
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 |
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| Is_Value_For_GDC_Property | ||
| label |
Levetiracetam
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|
| Legacy Concept Name |
Levetiracetam
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| Maps_To |
Levetiracetam
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| NCI_Drug_Dictionary_ID |
526173
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| PDQ_Closed_Trial_Search_ID |
526173
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| PDQ_Open_Trial_Search_ID |
526173
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| Preferred_Name |
Levetiracetam
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| prefixIRI |
NCIT:C47581
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| prefLabel |
Levetiracetam
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0377265
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| subClassOf |
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