loading...| Preferred Name |
Gastrointestinal Stromal Tumor |
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| Synonyms |
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| Definitions |
A stromal tumor most commonly seen in the gastrointestinal tract. Rare cases of solitary masses in the omentum or the mesentery have also been reported (extragastrointestinal gastrointestinal stromal tumor). It is a tumor that differentiates along the lines of interstitial cells of Cajal. Most cases contain KIT- or PDGFRA-activating mutations. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. Conventional chemotherapy and radiation therapy have been of limited value. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C3868 |
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| ALT_DEFINITION |
A type of tumor that usually begins in cells in the wall of the gastrointestinal tract. It can be benign or malignant. |
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| code |
C3868 |
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| Contributing_Source |
Cellosaurus CPTAC CTEP CTRP GDC |
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| definition |
A stromal tumor most commonly seen in the gastrointestinal tract. Rare cases of solitary masses in the omentum or the mesentery have also been reported (extragastrointestinal gastrointestinal stromal tumor). It is a tumor that differentiates along the lines of interstitial cells of Cajal. Most cases contain KIT- or PDGFRA-activating mutations. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. Conventional chemotherapy and radiation therapy have been of limited value. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases. |
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| Display_Name |
Gastrointestinal Stromal Tumor |
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| ICD-O-3_Code |
8936/1 |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C138190 http://purl.obolibrary.org/obo/NCIT_C168658 http://purl.obolibrary.org/obo/NCIT_C168656 http://purl.obolibrary.org/obo/NCIT_C168657 http://purl.obolibrary.org/obo/NCIT_C168655 http://purl.obolibrary.org/obo/NCIT_C158520 http://purl.obolibrary.org/obo/NCIT_C102905 http://purl.obolibrary.org/obo/NCIT_C168662 http://purl.obolibrary.org/obo/NCIT_C168661 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/ncit#oncotree_slim http://purl.obolibrary.org/obo/NCIT_C175325 http://purl.obolibrary.org/obo/NCIT_C156952 http://purl.obolibrary.org/obo/NCIT_C103117 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C126659 http://purl.obolibrary.org/obo/NCIT_C138188 http://purl.obolibrary.org/obo/NCIT_C165258 http://purl.obolibrary.org/obo/NCIT_C118168 |
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| Is_Value_For_GDC_Property | ||
| label |
Gastrointestinal Stromal Tumor |
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| Legacy Concept Name |
Gastrointestinal_Stromal_Tumor |
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| Maps_To |
Gastrointestinal stromal tumor, NOS 8936/1 GIST, NOS |
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| Neoplasm_Has_Special_Category | ||
| Neoplastic_Status |
Undetermined |
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| Preferred_Name |
Gastrointestinal Stromal Tumor |
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| prefixIRI |
NCIT:C3868 |
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| prefLabel |
Gastrointestinal Stromal Tumor |
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| Semantic_Type |
Neoplastic Process |
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| UMLS_CUI |
C3149028 |
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| subClassOf |