loading...| Preferred Name |
Chlorambucil |
|
| Synonyms |
|
|
| Definitions |
An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C362 |
|
| Accepted_Therapeutic_Use_For |
chronic lymphocytic leukemia, Hodgkin lymphoma, and certain types of non-Hodgkin lymphoma. |
|
| ALT_DEFINITION |
A drug used to treat several types of leukemias and lymphomas. It blocks cell growth by damaging the cell's DNA and may kill cancer cells. It is a type of alkylating agent. |
|
| CAS_Registry |
305-03-3 |
|
| CHEBI_ID |
CHEBI:28830 |
|
| Chemical_Formula |
C14H19Cl2NO2 |
|
| code |
C362 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04) |
|
| Display_Name |
Chlorambucil |
|
| FDA_UNII_Code |
18D0SL7309 |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Chlorambucil |
|
| Legacy Concept Name |
Chlorambucil |
|
| Maps_To |
Chlorambucil |
|
| NCI_Drug_Dictionary_ID |
43113 |
|
| NSC Number |
3088 |
|
| PDQ_Closed_Trial_Search_ID |
43113 |
|
| PDQ_Open_Trial_Search_ID |
43113 |
|
| Preferred_Name |
Chlorambucil |
|
| prefixIRI |
NCIT:C362 |
|
| prefLabel |
Chlorambucil |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0008163 |
|
| subClassOf |