loading...| Preferred Name |
Tumor Lysis Syndrome |
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| Synonyms |
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| Definitions |
A condition of metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells. Tumor lysis syndrome typically occurs in aggressive, rapidly proliferating lymphoproliferative disorders. Burkitt lymphoma and T cell acute lymphoblastic leukemia are commonly associated with this syndrome. Metabolic abnormalities include hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia and may result in renal failure, multiple organ failure, and death. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C3425 |
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| ALT_DEFINITION |
Multiple metabolic abnormalities resulting from tumor cell cytolysis characterized typically by hyperkalemia, hyperphosphatemia, hyperuricemia, and impaired renal function. A disorder characterized by metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells. A condition that can occur after treatment of a fast-growing cancer, especially certain leukemias and lymphomas (cancers of the blood). As tumor cells die, they break apart and release their contents into the blood. This causes a change in certain chemicals in the blood, which may cause damage to organs, including the kidneys, heart, and liver. |
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| code |
C3425 |
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| Contributing_Source |
CTRP MedDRA NICHD |
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| definition |
A condition of metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells. Tumor lysis syndrome typically occurs in aggressive, rapidly proliferating lymphoproliferative disorders. Burkitt lymphoma and T cell acute lymphoblastic leukemia are commonly associated with this syndrome. Metabolic abnormalities include hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia and may result in renal failure, multiple organ failure, and death. |
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| Display_Name |
Tumor Lysis Syndrome |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C90259 http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
Tumor Lysis Syndrome |
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| Legacy Concept Name |
Tumor_Lysis_Syndrome |
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| Maps_To |
Tumor lysis syndrome |
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| Preferred_Name |
Tumor Lysis Syndrome |
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| prefixIRI |
NCIT:C3425 |
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| prefLabel |
Tumor Lysis Syndrome |
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| Semantic_Type |
Disease or Syndrome |
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| UMLS_CUI |
C0041364 |
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| subClassOf |