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Cancer Care: Treatment Outcome Ontology
Last uploaded:
July 29, 2018
| Acronym | CCTOO |
| Visibility | Public |
| Description | The Cancer Care: Treatment Outcomes Ontology (CCTOO) catalogues various clinical endpoints used in evaluating outcomes of cancer treatment. In addition to a vocabulary list, CCTOO also curates the dependencies between individual concepts, in form of production rules, for translating clinical findings recorded in the electronic medical records (EMR) into literature-based concepts. An earlier version of this ontology was presented as a scientific abstract alongside the American Society of Clinical Oncology annual meeting 2017, Chicago, USA (J Clin Oncol 2017; 35 suppl; abstr e18137). Full paper on http://ascopubs.org/doi/abs/10.1200/CCI.18.00026 |
| Status | Beta |
| Format | OBO |
| Contact | Frank Lin, f.lin@garvan.org.au |
| Categories | Biomedical Resources, Health, Human |
- Hypermethylation
- Hypermethylation is an epigenetic feature that occurs when DNA is increased in methylation, which can modify gene expression. It can be caused by a number of factors, including drugs like cisplatin and topoisomerase inhibitors. Hypermethylation can have a number of effects, including: Cancer Hypermethylation can inactivate tumor suppressor genes, which can lead to the formation of tumors. It can also be a marker for poor prognosis in some cancers, such as lung cancer. Overmethylation disorder Also known as Low-Folate disorder, hypermethylation can cause a range of symptoms, including anxiety, panic attacks, sleep disorders, and sensitivities to environmental toxins. Other symptoms include rapid speech, low libido, dry eyes and mouth, low motivation, self-mutilation, and paranoia