Preferred Name |
Camptothecin |
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Synonyms |
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|
Definitions |
An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI) |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C338 |
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ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors. |
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CAS_Registry |
7689-03-4 |
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CHEBI_ID |
CHEBI:27656 |
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Chemical_Formula |
C20H16N2O4 |
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code |
C338 |
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Contributing_Source |
FDA |
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definition |
An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI) |
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FDA_UNII_Code |
XT3Z54Z28A |
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Has_Salt_Form | ||
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C128784 |
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Is_Value_For_GDC_Property | ||
label |
Camptothecin |
|
Legacy Concept Name |
Camptothecin |
|
Maps_To |
Camptothecin |
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NCI_Drug_Dictionary_ID |
39173 |
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NSC Number |
94600 |
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PDQ_Closed_Trial_Search_ID |
39173 |
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PDQ_Open_Trial_Search_ID |
39173 |
|
Preferred_Name |
Camptothecin |
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prefixIRI |
NCIT:C338 |
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prefLabel |
Camptothecin |
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Semantic_Type |
Organic Chemical Pharmacologic Substance |
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UMLS_CUI |
C0006812 |
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subClassOf |