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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Camptothecin | |
| Synonyms |
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| Definitions |
An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C338 |
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| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.
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| CAS_Registry |
7689-03-4
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| CHEBI_ID |
CHEBI:27656
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| Chemical_Formula |
C20H16N2O4
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| code |
C338
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| Contributing_Source |
FDA
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| definition |
An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI)
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| FDA_UNII_Code |
XT3Z54Z28A
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| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Camptothecin
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| Legacy Concept Name |
Camptothecin
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| Maps_To |
Camptothecin
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| NCI_Drug_Dictionary_ID |
39173
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| NSC Number |
94600
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| PDQ_Closed_Trial_Search_ID |
39173
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| PDQ_Open_Trial_Search_ID |
39173
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| Preferred_Name |
Camptothecin
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| prefixIRI |
NCIT:C338
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| prefLabel |
Camptothecin
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0006812
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| subClassOf |
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