Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Preferred Name	Topoisomerase-I Inhibitor
Synonyms
Definitions	Any substance that inhibits topoisomerase-I, a topoisomerase that relieves torsional stress in a DNA molecule by cutting only one strand of the DNA double helix. Inhibition of topoisomerase-I causes DNA damage, inhibition of DNA replication, and apoptosis.
ID	http://purl.obolibrary.org/obo/NCIT_C1904
CHEBI_ID	CHEBI:50276
code	C1904
definition	Any substance that inhibits topoisomerase-I, a topoisomerase that relieves torsional stress in a DNA molecule by cutting only one strand of the DNA double helix. Inhibition of topoisomerase-I causes DNA damage, inhibition of DNA replication, and apoptosis.
label	Topoisomerase-I Inhibitor
Legacy Concept Name	Topoisomerase-I_Inhibitor
Preferred_Name	Topoisomerase-I Inhibitor
prefixIRI	NCIT:C1904
prefLabel	Topoisomerase-I Inhibitor
Semantic_Type	Chemical Viewed Functionally
UMLS_CUI	C0594374
subClassOf	http://purl.obolibrary.org/obo/NCIT_C1748

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Mapping To	Ontology	Source
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1904	NCIT	LOOM
http://purl.bioontology.org/ontology/npo#NPO_864	NPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_50276	DINTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_50276	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_50276	CHIRO	LOOM