Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Clozapine
Synonyms
Definitions

A synthetic dibenzo-diazepine derivative, atypical antipsychotic Clozapine blocks several neurotransmitter receptors in the brain (dopamine type 4, serotonin type 2, norepinephrine, acetylcholine, and histamine receptors). Unlike traditional antipsychotic agents, it weakly blocks dopamine type 2 receptors. It relieves schizophrenic symptoms (hallucinations, delusions, dementia). (NCI04)
ID

http://purl.obolibrary.org/obo/NCIT_C28936
CAS_Registry

5786-21-0
CHEBI_ID

CHEBI:3766
Chemical_Formula

C18H19ClN4
code

C28936
Contributing_Source

FDA
definition

A synthetic dibenzo-diazepine derivative, atypical antipsychotic Clozapine blocks several neurotransmitter receptors in the brain (dopamine type 4, serotonin type 2, norepinephrine, acetylcholine, and histamine receptors). Unlike traditional antipsychotic agents, it weakly blocks dopamine type 2 receptors. It relieves schizophrenic symptoms (hallucinations, delusions, dementia). (NCI04)
FDA_UNII_Code

J60AR2IKIC
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C176424
label

Clozapine
Legacy Concept Name

Clozapine
NCI_Drug_Dictionary_ID

800675
PDQ_Closed_Trial_Search_ID

800675
PDQ_Open_Trial_Search_ID

800675
Preferred_Name

Clozapine
prefixIRI

NCIT:C28936
prefLabel

Clozapine
Semantic_Type

Organic Chemical

Pharmacologic Substance
UMLS_CUI

C0009079
subClassOf

http://purl.obolibrary.org/obo/NCIT_C94726

http://purl.obolibrary.org/obo/NCIT_C29710
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http://purl.jp/bio/4/id/200906010315840084 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/2626 RXNORM LOOM
http://purl.bioontology.org/ontology/SNMI/C-63420 SNMI LOOM
http://www.drugbank.ca/drugs/DB00363 FTC LOOM
http://purl.bioontology.org/ontology/VANDF/4019488 VANDF LOOM
http://purl.bioontology.org/ontology/CSP/0314-4862 CRISP LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0009079 OCHV LOOM
http://purl.bioontology.org/ontology/ATC/N05AH02 ATC LOOM
http://bmi.utah.edu/ontologies/hfontology/C0009079 HFO LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Clozapine APAONTO LOOM
http://stirdf.jst.go.jp/id/200907078191585002 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3080 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147608 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003024 RH-MESH LOOM
http://purl.obolibrary.org/obo/XCO_0001149 XCO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017964 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/LNC/LP17236-8 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 ECTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 OBA LOOM
http://purl.bioontology.org/ontology/RCD/d4l.. RCD LOOM
http://purl.bioontology.org/ontology/MESH/D003024 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/003526 NDDF LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass932c0f47_bb57_4af6_8363_b1a0865e0abc WWECA LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass2ef82e3f_2080_48b9_9bdc_911c8602ab28 WWECA LOOM
http://purl.obolibrary.org/obo/OMIT_0004334 OMIT LOOM
http://www.co-ode.org/ontologies/galen#Clozapine GALEN LOOM
http://purl.bioontology.org/ontology/CPT/80159 CPT LOOM
https://go.drugbank.com/drugs/DB00363 MDM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060461 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.494.240.220 RH-MESH LOOM
http://www.case.edu/EpSO.owl#Clozapine MEPO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28936 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387568001 SNOMEDCT LOOM
http://www.case.edu/EpilepsyOntology.owl#Clozapine EPSO LOOM