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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Proteasome Inhibitor | |
| Synonyms |
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| Definitions |
Any substance that inhibits the proteasome complex, an enzyme complex responsible for degradation of ubiquitinated proteins. Inhibition of proteasome activity and ubiquitin-proteasome mediated proteolysis results in an accumulation of poly-ubiquitinated proteins, which may result in the disruption of cellular processes, cell cycle arrest, the induction of apoptosis, and the inhibition of tumor growth and angiogenesis. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C2160 |
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| ALT_DEFINITION |
A drug that blocks the action of proteasomes. A proteasome is a large protein complex that helps destroy other cellular proteins when they are no longer needed. Proteasome inhibitors are being studied in the treatment of cancer.
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| CHEBI_ID |
CHEBI:52726
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| code |
C2160
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| definition |
Any substance that inhibits the proteasome complex, an enzyme complex responsible for degradation of ubiquitinated proteins. Inhibition of proteasome activity and ubiquitin-proteasome mediated proteolysis results in an accumulation of poly-ubiquitinated proteins, which may result in the disruption of cellular processes, cell cycle arrest, the induction of apoptosis, and the inhibition of tumor growth and angiogenesis.
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| label |
Proteasome Inhibitor
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| Legacy Concept Name |
Proteasome_Inhibitor
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| Preferred_Name |
Proteasome Inhibitor
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| prefixIRI |
NCIT:C2160
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| prefLabel |
Proteasome Inhibitor
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| Semantic_Type |
Chemical Viewed Functionally
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| UMLS_CUI |
C1443643
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| subClassOf |
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