Targeted Therapy Agent

Any agent that specifically targets or interferes with the synthesis or function of a molecule that is expressed specifically in or on cells of the tumor and/or the tumor microenvironment (TME), such as immune cells or surrounding blood vessels. The targeted molecule is usually overexpressed or mutated in tumors but minimally or not expressed by normal, healthy tissues; additionally, expression is typically associated with tumor cell proliferation, progression and/or survival. By blocking the function or expression of the tumor-associated target, the targeted therapy agent may exert potential antineoplastic and/or immunomodulatory activities.

http://purl.obolibrary.org/obo/NCIT_C163758

C163758

Any agent that specifically targets or interferes with the synthesis or function of a molecule that is expressed specifically in or on cells of the tumor and/or the tumor microenvironment (TME), such as immune cells or surrounding blood vessels. The targeted molecule is usually overexpressed or mutated in tumors but minimally or not expressed by normal, healthy tissues; additionally, expression is typically associated with tumor cell proliferation, progression and/or survival. By blocking the function or expression of the tumor-associated target, the targeted therapy agent may exert potential antineoplastic and/or immunomodulatory activities.

Includes mainly antibodies, small molecules and antibody-drug conjugates (ADCs). As of September 2019, this therapy agent tree does not include immune cells, such as CAR-T cells, vaccines, gene therapy agents and radio(immuno)conjugates. Targets featured in this tree are the most common targets against which agents are being developed or have been approved. New target/agent categories in this tree will be identified and added based on user needs and new drug developments.

http://purl.obolibrary.org/obo/NCIT_C128784

Targeted Therapy Agent

CL976985

Targeted Therapy Agent

NCIT:C163758

Targeted Therapy Agent

Pharmacologic Substance

Classification

http://purl.obolibrary.org/obo/NCIT_C274