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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Cadherin-5 | |
| Synonyms |
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| Definitions |
Cadherin-5 (784 aa, ~88 kDa) is encoded by the human CDH5 gene. This protein is involved in endothelial cell polarity and cell-cell adhesion. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C21021 |
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| code |
C21021
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| definition |
Cadherin-5 (784 aa, ~88 kDa) is encoded by the human CDH5 gene. This protein is involved in endothelial cell polarity and cell-cell adhesion.
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| DesignNote |
Encoded by human CDH5 Gene (CDH Family), 784-amino acid 87.5 kD (precursor) Vascular Endothelial Cadherin is a Ca(2+)-dependent homophilic endothelial cell-cell adhesion type I membrane glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Expressed specifically in endothelial cells and brain, VE-Cadherin is found mainly at cell-cell boundaries, associated with intercellular junctions. CDH5 may play a role in endothelial cell cohesion and organization of intercellular junctions. CDH5/beta-catenin signaling may control endothelial survival. CDH5 associates with alpha-catenin, forming a link to the cytoskeleton.
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| label |
Cadherin-5
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| Legacy Concept Name |
VE-Cadherin
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| OMIM_Number |
601120
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| Preferred_Name |
Cadherin-5
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| prefixIRI |
NCIT:C21021
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| prefLabel |
Cadherin-5
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| Semantic_Type |
Amino Acid, Peptide, or Protein
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| Swiss_Prot |
P33151
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| UMLS_CUI |
C1741231
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| subClassOf |
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