loading...| Preferred Name | Cadherin | |
| Synonyms |
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| Definitions |
The cadherins are transmembrane glycoproteins involved in calcium dependent specific cell-cell adhesion through homophilic binding. They are crucial for morphogenesis and synapse formation, but also are involved in tumor invasion. The classical cadherins have five homologous extracellular domains and a cytosolic domain which binds through catenin to the cytoskeleton. The extracellular domains are immunoglobulin-like beta-sandwiches comprising usually 7 strands in the two sheets. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C16373 |
|
| code |
C16373 |
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| definition |
The cadherins are transmembrane glycoproteins involved in calcium dependent specific cell-cell adhesion through homophilic binding. They are crucial for morphogenesis and synapse formation, but also are involved in tumor invasion. The classical cadherins have five homologous extracellular domains and a cytosolic domain which binds through catenin to the cytoskeleton. The extracellular domains are immunoglobulin-like beta-sandwiches comprising usually 7 strands in the two sheets. |
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| label |
Cadherin |
|
| Legacy Concept Name |
Cadherin |
|
| Preferred_Name |
Cadherin |
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| prefixIRI |
NCIT:C16373 |
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| prefLabel |
Cadherin |
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| Semantic_Type |
Amino Acid, Peptide, or Protein |
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| UMLS_CUI |
C0006631 |
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| subClassOf |