loading...| Preferred Name |
Lorazepam |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassf6dd52d3_33a9_4690_8c32_d2ed70d120f2 |
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| Chinese |
劳拉西泮 |
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| label |
Lorazepam |
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| MESH_Definition |
A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. |
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| NCIt_Definition |
A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation. |
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| prefLabel |
Lorazepam |
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| SIGN_Guidance |
If there is doubt whether a seizure in labour is due to eclampsia or epilepsy, a slow intravenous bolus of 4 g magnesium sulphate over five minutes followed by 1 g/hour for 24 hours is recommended in addition to midazolam, lorazepam or diazepam. 如果不能明确分娩过程中的痫性发作是由子痫引起还是由癫痫引起，建议在米达唑仑、劳拉西泮或地西泮的基础上，5min内缓慢静注硫酸镁4g，之后1g/h，持续24h。 Scottish Intercollegiate Guidelines Network.Diagnosis and management of epilepsy in adults. SIGN 143. Edinburgh, SIGN, 2015. Available at: www.sign.ac.uk/guidelines/fulltext/143/index.html |
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| Synonyms |
lorazepam o-Chlorooxazepam 7-Chloro-5-(2-chlorophenyl)-1 3-Dihydro-3-Hydroxy-14- Benzodiazepin-2-one LORazepam Wyeth Orfidal Orfidal Wyeth Ativan LORAZEPAM 846-49-1 Product containing lorazepam (medicinal product) 289758 Lorazepam (substance) o-Chloroxazepam Loracepam Témesta Lorazepam-containing product 7-chloro-5-(2-chlorophenyl)-1 3-dihydro-3-Hydroxy-14- benzodiazepin-2-one Lorazepam 2H-14-Benzodiazepin-2-one 7-chloro-5-(2-chlorophenyl)-13-dihydro-3-hydroxy- |
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| subClassOf |