loading...| Preferred Name |
Doxepin |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassd75d3dde_3726_43b1_91d6_02fc30c7e388 |
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| Chinese |
多塞平 |
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| label |
Doxepin |
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| MESH_Definition |
A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors. |
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| NCIt_Definition |
A dibenzoxepin derivative and tricyclic antidepressant (TCA) with antipruritic, antidepressive and anxiolytic activities. Doxepin blocks the reuptake of norepinephrine and serotonin (5-HT) into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their neurotransmission. Doxepin also has antagonistic effects on histamine H1, 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is mediated through inhibition of histamine receptors. |
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| prefLabel |
Doxepin |
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| Synonyms |
Doxepin (substance) Silenor Doxepin-containing product 1-Propanamine 3-dibenz(be)oxepin-11(6H)-ylidene-NN-dimethyl- DOXEPIN Product containing doxepin (medicinal product) Doxepinum Doxepina |
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