loading...| Preferred Name |
Sevoflurane |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassb81065d0_b48b_49f6_8eef_792225809f29 |
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| Chinese |
七氟烷 |
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| label |
Sevoflurane |
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| MESH_Definition |
A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION. |
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| NCIt_Definition |
A fluorinated isopropyl ether with general anesthetic property. Although the mechanism of action has not been fully elucidated, sevoflurane may act by interfering with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter ionic conductance following receptor activation by a neurotransmitter. Sevoflurane may also interact directly with lipid matrix of neuronal membranes, thereby affecting gating properties of ion channels. In addition, this agent may activate gamma-aminobutyric acid (GABA) receptors hyperpolarizing cell membranes. This results in a general anesthetic effect, a decrease in myocardial contractility and mean arterial pressure as well as an increased respiratory rate. |
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| prefLabel |
Sevoflurane |
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| ROCG_Guidance |
[GRADES OF RECOMMENDATION:D] Pethidine should be used with caution in WWE for analgesia in labour. Diamorphine should be used in preference to pethidine.（Pethidine is metabolised to norpethidine, which is known to be epileptogenic when administered in high doses to patients with normal renal function. If general anaesthesia becomes necessary, it is prudent to avoid anaesthetic agents such as pethidine, ketamine and sevoflurane. The first two are known to lower seizure threshold and the third may have epileptogenic potential.） 【推荐等级：D】WWE分娩镇痛时慎用哌替啶，二氢吗啡应优先于哌替啶使用。（哌替啶可被代谢为去甲哌替啶，后者在肾功能正常的患者中可引起癫痫发作（大剂量）。全麻时避免使用哌替啶、氯胺酮和七氟醚等麻醉剂，前两种药物可降低癫痫发作阈值，第三种可致痫。） https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/epilepsy-in-pregnancy-green-top-guideline-no-68/ |
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| Synonyms |
sevoflurane Fluoromethyl Hexafluoroisopropyl Ether Sevofluran Ether Fluoromethyl 222-trifluoro-1-(trifluoromethyl)ethyl- Product containing sevoflurane (medicinal product) Propane 111333-hexafluoro-2-(fluoromethoxy)- Sevoflurane-containing product Sevoflurane (substance) Ultane Sevoflurano Fluoromethyl-222-trifluoro-1-(trifluoromethyl)ethyl Ether 28523-86-6 SEVOFLURANE Sevoflurane 111333-Hexafluoro-2-(fluoromethoxy)propane Sevorane Fluoromethyl 222-trifluoro-1-(trifluromethyl)ethyl ether Sevofluranum |
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