loading...| Preferred Name |
Tiagabine |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassa154eb8d_990a_4e91_92c1_3b880d1d2434 |
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| China_guidence |
孕前咨询：告知患者癫痫发作及AEDs对妊娠及胎儿风险。妊娠期使用AEDs可能对癫痫女性后代智力发育造成影响，尤其是苯巴比妥和丙戊酸。目前尚无足够的证据来评估新型AEDs（加巴喷丁、左乙拉西坦、噻加宾、托吡酯、氨己烯酸）的致畸性。大剂量丙戊酸（超过800mg/天）以及联合丙戊酸的多药治疗的致畸风险明显增加；告知患者补充叶酸和维生素K的必要性。如果孕妇或者配偶有癫痫疾病，尤其是有特发性癫痫及癫痫及相关遗传病家族史者，应当进行遗传咨询。 Li, S. and Hong, Z., 2015. Lin chuang zhen liao zhi nan. Beijing: Ren min wei sheng chu ban she. 哺乳：绝大多数AEDs可以通过乳汁分泌，但是乳汁中AEDs的浓度相对比较低；对于绝大多数服用AEDs的妇女来说，哺乳相对是安全的，应当鼓励母乳喂养；注意婴儿的不良反应，如易激惹、睡眠不良、体重减轻或镇静、肌张力降低、吸吮无力、进食困难等现象。 Li, S. and Hong, Z., 2015. Lin chuang zhen liao zhi nan. Beijing: Ren min wei sheng chu ban she. |
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| Chinese |
噻加宾 |
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| label |
Tiagabine |
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| MESH_Definition |
A nipecotic acid derivative that acts as a GABA uptake inhibitor and anticonvulsant agent. It is used in the treatment of EPILEPSY, for refractory PARTIAL SEIZURES. |
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| prefLabel |
Tiagabine |
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| Synonyms |
Tiagabine Hydrochloride Gabitril NO 328 NO-328 NO 329 (R)-(44-bis(3-Methyl-2-thienyl)-3-butenyl)-3-piperidinecarboxylic acid Hydrochloride Tiagabine (S)-isomer NO-329 tiagabine N-(44-di(3-Methylthien-2-yl)but-3-enyl)nipecotic acid Tiagabine-containing product Tiagabine (substance) Tiagabina Product containing tiagabine (medicinal product) Tiagabinum 3-Piperidinecarboxylic acid 1-(44-bis(3-methyl-2-thienyl)-3-buten-1-yl)- (3R)- |
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