loading...| Preferred Name |
Naltrexone |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass9a587443_7cc8_4915_a6bb_b7813fba79b7 |
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| Chinese |
纳曲酮 |
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| label |
Naltrexone |
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| MESH_Definition |
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. |
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| NCIt_Definition |
A noroxymorphone derivative with competitive opioid antagonistic property. Naltrexone reverses the effects of opioid analgesics by binding to the various opioid receptors in the central nervous system, including the mu-, kappa- and gamma-opioid receptors. This leads to an inhibition of the typical actions of opioid analgesics, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. Naltrexone is longer-acting and more potent compared to naloxone. |
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| prefLabel |
Naltrexone |
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| Synonyms |
Naltrexone-containing product vivitrol 17-(Cyclopropylmethyl)-45α-epoxy-314-dihydroxymorphinan-6-one Naltrexone Morphinan-6-one 17-(cyclopropylmethyl)-45-epoxy-314-dihydroxy- (5alpha)- Naltrexon N-Cyclopropylmethylnoroxymorphone Naltrexonum 17-(Cyclopropylmethyl)-45-epoxy-314-dihydroxymorphinan-6-one Naltrexone (substance) N-Cyclopropylmethyl-14-hydroxydihydromorphinone Naltrexona Product containing naltrexone (medicinal product) |
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