Levetiracetam

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左乙拉西坦

Levetiracetam

A pyrrolidinone and acetamide derivative that is used primarily for the treatment of SEIZURES and some movement disorders, and as a nootropic agent.

A pyrrolidine with antiepileptic activity. The exact mechanism through which levetiracetam exerts its effects is unknown but does not involve inhibitory and excitatory neurotransmitter activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity.

Levetiracetam

[GRADES OF RECOMMENDATION:C] Based on limited evidence, in utero exposure to carbamazepine and lamotrigine does not appear to adversely affect neurodevelopment of the offspring. There is very little evidence for levetiracetam and phenytoin. Parents should be informed that evidence on long-term outcomes is based on small numbers of children. 【推荐等级：C】应告知WWE及其伴侣，关于宫内暴露于AEDs产生的长期神经发育结果是基于少数儿童的。有限的证据表示，宫内接触CBZ和LTG似乎不会影响后代神经生长发育；使用LEV和PHT的证据很少。 https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/epilepsy-in-pregnancy-green-top-guideline-no-68/

[GRADES OF RECOMMENDATION:D] Parents should be made aware of signs of toxicity in infants of breastfeeding women taking antiepileptic drugs. The possibility of sedation should be considered in infants of mothers taking high dose antiepileptic drugs, polytherapy, or regimens including primidone, levetiracetam, gabapentin, lamotrigine and topiramate. D级推荐：应告知女性癫痫患者及其伴侣，哺乳期服用AEDs可能对新生儿/婴儿有不良影响。服用大剂量AEDs、综合疗法或采用包含扑米酮、左乙拉西坦、加巴喷丁、拉莫三嗪和托吡酯在内的治疗方案的哺乳期母亲婴儿可能会有镇静的副作用。 Scottish Intercollegiate Guidelines Network.Diagnosis and management of epilepsy in adults. SIGN 143. Edinburgh, SIGN, 2015. Available at: www.sign.ac.uk/guidelines/fulltext/143/index.html

Ucb L059 UcbL060 Etiracetam (R)- alpha-ethyl-2-oxo-1-Pyrrolidineacetamide UCB-6474 Ucb L060 UCB6474 Ucb-L060 UCB 6474 R-isomer Etiracetam alpha ethyl 2 oxo 1 Pyrrolidineacetamide Etiracetam R isomer Ucb-L059 Etiracetam Etiracetam R-isomer Levetiracetam-containing product S-isomer Etiracetam Keppra Levetiracetam (substance) (S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetamide Levetiracetam Levetiracetamum 1-pyrrolidineacetamide alpha-ethyl-2-oxo-(S)- Etiracetam S-isomer Levetiracetame Product containing levetiracetam (medicinal product) Etiracetam S isomer 102767-28-2 1-Pyrrolidineacetamide alpha-ethyl-2-oxo- (alphaS)-

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