loading...| Preferred Name |
Pregabalin |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass6ac5698d_d681_45b1_9e60_746a2e4dbdbf |
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| Belgium_recommandations |
除拉莫三嗪、左乙拉西坦、奥卡西平、普瑞巴林外，其余AEDs均为妊娠期女性癫痫患者慎用药物，其中丙戊酸为禁用药物。 Mauri Llerda JA, Suller Marti A, de la Peña Mayor P, Martínez Ferri M, Poza Aldea JJ, Gomez Alonso J, Mercadé Cerdá JM. The Spanish Society of Neurology's official clinical practice guidelines for epilepsy. Special considerations in epilepsy: comorbidities, women of childbearing age, and elderly patients. Neurologia. 2015 Oct;30(8):510-7. English, Spanish. doi: 10.1016/j.nrl.2014.08.002. Epub 2015 Jan 21. PMID: 25618222. |
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| Chinese |
普瑞巴林 |
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| label |
Pregabalin |
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| MESH_Definition |
A gamma-aminobutyric acid (GABA) derivative that functions as a CALCIUM CHANNEL BLOCKER and is used as an ANTICONVULSANT as well as an ANTI-ANXIETY AGENT. It is also used as an ANALGESIC in the treatment of NEUROPATHIC PAIN and FIBROMYALGIA. |
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| NCIt_Definition |
A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation. |
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| prefLabel |
Pregabalin |
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| Synonyms |
3-(Aminomethyl)-5-methyl-hexanoic Acid CI1008 3-(aminomethyl)-5-methyl-hexanoic acid Pregabalin (substance) 3-(aminomethyl)-5-methylhexanoic acid (R-)-3-isobutyl GABA Product containing pregabalin (medicinal product) (S)-3-Isobutyl GABA CI-1008 3-Isobutyl GABA 3 isobutyl GABA 3-isobutyl GABA Pregabalin-containing product PD 144723 GABA 3-isobutyl pregabalin Pregabalina (S)-3-(aminomethyl)-5-methylhexanoic acid PD-144723 CI 1008 (S+)-3-isobutyl GABA 1008 CI Pregabalin Lyrica PREGABALIN |
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