Sodium valproate

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丙戊酸钠

A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.

The sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blood. Although the mechanism of action remains to be elucidated, valproate sodium increases concentrations of gamma-aminobutyric acid (GABA) in the brain, probably due to inhibition of the enzymes responsible for the catabolism of GABA. This potentiates the synaptic actions of GABA. Valproate sodium may also affect potassium channels, thereby creating a direct membrane-stabilizing effect.

Sodium valproate

[GRADES OF RECOMMENDATION:C] WWE and their partners need to be informed about the possible adverse impact on long-term neurodevelopment of the newborn following in utero exposure to sodium valproate. 【推荐等级：C】应告知WWE及其伴侣，宫内暴露于VPA可能对其长期神经发育产生不利影响。 Exposure to sodium valproate and other AED polytherapy should be minimised by changing the medication prior to conception, as recommended by an epilepsy specialist after a careful evaluation of the potential risks and benefits. 孕前使用VPA和其他AEDs综合治疗的患者，应根据癫痫专家的评估和建议下，在孕前即更换药物，以最大限度减少风险。 https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/epilepsy-in-pregnancy-green-top-guideline-no-68/

Wherever possible sodium valproate should be avoided during pregnancy.For women of childbearing potential, particularly those women contemplating pregnancy, other antiepileptic drugs should be considered in preference to sodium valproate. However, sodium valproate might be the only effective antiepileptic drug for some women, and this should not preclude its use. 妊娠期间应尽可能避免使用VPA或包括VPA在内的综合治疗方案。对于育龄期女性，尤其是有计划怀孕的女性，应优先考虑除了VPA以外的AEDs（但在某些不得不使用VPA的情况下，仍应使用VPA）。 Scottish Intercollegiate Guidelines Network.Diagnosis and management of epilepsy in adults. SIGN 143. Edinburgh, SIGN, 2015. Available at: www.sign.ac.uk/guidelines/fulltext/143/index.html

[GRADES OF RECOMMENDATION:D] Women with epilepsy should be informed that sodium valproate is associated with a higher rate of teratogenicity compared to other antiepileptic drugs.Antiepileptic drug polytherapy regimens including sodium valproate are associated with higher rates of congenital malformations compared to regimens not including sodium valproate. D级推荐：应告知所有女性癫痫患者，与其他AEDs相比，使用VPA有更高的致畸率；与不包括VPA在内的综合治疗方案相比，包含VPA的综合治疗方案致畸率更高。 Scottish Intercollegiate Guidelines Network.Diagnosis and management of epilepsy in adults. SIGN 143. Edinburgh, SIGN, 2015. Available at: www.sign.ac.uk/guidelines/fulltext/143/index.html

Sodium dipropylacetate Depacon DPA sodium VALPROATE SODIUM 2-Propylpentanoic Acid Sodium Salt Sodium Valproate Sodium alpha-propylvalerate Ergenyl Valproate sodium (substance) Convulsofin Vupral Magnesium Valproate Valproic Acid Sodium Salt (2:1) Semisodium Valproate Calcium Valproate Depakote Divalproex Sodium Valproate Calcium Dipropyl Acetate

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