loading...| Preferred Name |
Diazepam |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass530c3316_d6fd_4035_80f0_4458a8890e7d |
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| Chinese |
地西泮 |
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| label |
Diazepam |
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| MESH_Definition |
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity. |
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| NCIt_Definition |
A benzodiazepine derivative with anti-anxiety, sedative, hypnotic and anticonvulsant properties. Diazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic system and the hypothalamus. This increases the frequency of chloride channel opening, allowing the flow of chloride ions into the neuron and ultimately leading to membrane hyperpolarization and a decrease in neuronal excitability. |
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| prefLabel |
Diazepam |
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| SIGN_Guidance |
If there is doubt whether a seizure in labour is due to eclampsia or epilepsy, a slow intravenous bolus of 4 g magnesium sulphate over five minutes followed by 1 g/hour for 24 hours is recommended in addition to midazolam, lorazepam or diazepam. 如果不能明确分娩过程中的痫性发作是由子痫引起还是由癫痫引起，建议在米达唑仑、劳拉西泮或地西泮的基础上，5min内缓慢静注硫酸镁4g，之后1g/h，持续24h。 Scottish Intercollegiate Guidelines Network.Diagnosis and management of epilepsy in adults. SIGN 143. Edinburgh, SIGN, 2015. Available at: www.sign.ac.uk/guidelines/fulltext/143/index.html |
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| Synonyms |
Diazemuls Relanium Seduxen Sibazon Apaurin Faustan Stesolid diazepam Valium Diazepam-containing product Diazepam (substance) 7-chloro-13-dihydro-1-methyl-5-phenyl-2H-14-benzodiazepin-2-one Methyl diazepinone Product containing diazepam (medicinal product) 2H-14-Benzodiazepin-2-one 7-chloro-13-dihydro-1-methyl-5-phenyl- |
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| subClassOf |