loading...| Preferred Name |
Topiramate |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass42d18b2b_8c13_437e_b7c7_9d2434a3e154 |
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| Chinese |
托吡酯 |
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| label |
Topiramate |
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| MESH_Definition |
A sulfamate-substituted fructose analog that was originally identified as a hypoglycemic agent. It is used for the treatment of EPILEPSY and MIGRAINE DISORDERS, and may also promote weight loss. |
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| NCIt_Definition |
A sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission. |
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| prefLabel |
Topiramate |
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| ROCG_Guidance |
[GRADES OF RECOMMENDATION:C] Women taking enzyme-inducing AEDs (carbamazepine, phenytoin, phenobarbital, primidone, oxcarbazepine, topiramate and eslicarbazepine) should be counselled about the risk of failure with some hormonal contraceptives. 【推荐等级：C】应告知服用酶诱导型AEDs（卡马西平、苯妥英、苯巴比妥、扑米酮、奥卡西平、托吡酯、艾司利卡西平）的WWE避孕失败的风险。 https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/epilepsy-in-pregnancy-green-top-guideline-no-68/ |
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| SIGN_Guidance |
[GRADES OF RECOMMENDATION:D] Parents should be made aware of signs of toxicity in infants of breastfeeding women taking antiepileptic drugs. The possibility of sedation should be considered in infants of mothers taking high dose antiepileptic drugs, polytherapy, or regimens including primidone, levetiracetam, gabapentin, lamotrigine and topiramate. D级推荐：应告知女性癫痫患者及其伴侣，哺乳期服用AEDs可能对新生儿/婴儿有不良影响。服用大剂量AEDs、综合疗法或采用包含扑米酮、左乙拉西坦、加巴喷丁、拉莫三嗪和托吡酯在内的治疗方案的哺乳期母亲婴儿可能会有镇静的副作用。 Scottish Intercollegiate Guidelines Network.Diagnosis and management of epilepsy in adults. SIGN 143. Edinburgh, SIGN, 2015. Available at: www.sign.ac.uk/guidelines/fulltext/143/index.html |
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| Synonyms |
Epitomax USL255 McN 4853 McN4853 McN-4853 Topiramate Tipiramate Tipiramato 23:45-di-O-isopropylidene-β-D-fructopyranose sulfamate beta-D-Fructopyranose 23:45-bis-O-(1-methylethylidene)- sulfamate TPM Topamax Product containing topiramate (medicinal product) Topiramate-containing product 23:45-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate Topiramato 23-45-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate Topiramate (substance) Topiramatum 97240-79-4 |
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