loading...| Preferred Name |
Zonisamide |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass3d7cd44d_cdb8_437b_90eb_44115e5a9430 |
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| Chinese |
唑尼沙胺 |
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| label |
Zonisamide |
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| MESH_Definition |
A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization. |
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| NCIt_Definition |
A sulfonamide derivative with an anticonvulsant property. The exact mechanism of action remains to be elucidated. Zonisamide appears to block sodium and calcium channels, thereby stabilizing neuronal membranes and suppressing neuronal hyper-synchronization. Although zonisamide shows affinity for the gamma-aminobutyric acid (GABA)/benzodiazepine receptor ionophore complex, it does not potentiate the synaptic activity of GABA. In addition, this agent also facilitates both dopaminergic and serotonergic neurotransmission. |
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| prefLabel |
Zonisamide |
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| Synonyms |
AD 810 Zonisamide Monosodium CI912 AD810 CI-912 CI 912 AD-810 zonisamide Zonisamide-containing product Product containing zonisamide (medicinal product) Zonisamide (substance) Excegram 3-Sulfamoylmethyl-12-benzisoxazole 3 Sulfamoylmethyl 12 benzisoxazole 12-Benzisoxazole-3-methanesulfonamide Zonisamidum Benzo[d]isoxazol-3-yl-methanesulfonamide Zonegran 3-(Sulfamoylmethyl)-12-benzisoxazole Zonisamida |
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