loading...| Preferred Name |
Pregabalin |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass3905e641_d161_430f_bf72_7cd666091ef5 |
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| Chinese |
普瑞巴林 |
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| label |
Pregabalin |
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| MESH_Definition |
A gamma-aminobutyric acid (GABA) derivative that functions as a CALCIUM CHANNEL BLOCKER and is used as an ANTICONVULSANT as well as an ANTI-ANXIETY AGENT. It is also used as an ANALGESIC in the treatment of NEUROPATHIC PAIN and FIBROMYALGIA. |
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| NCIt_Definition |
A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation. |
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| prefLabel |
Pregabalin |
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| Synonyms |
3-(Aminomethyl)-5-methyl-hexanoic Acid CI1008 3-(aminomethyl)-5-methyl-hexanoic acid Pregabalin (substance) 3-(aminomethyl)-5-methylhexanoic acid (R-)-3-isobutyl GABA Product containing pregabalin (medicinal product) (S)-3-Isobutyl GABA CI-1008 3-Isobutyl GABA 3 isobutyl GABA 3-isobutyl GABA Pregabalin-containing product PD 144723 GABA 3-isobutyl pregabalin Pregabalina (S)-3-(aminomethyl)-5-methylhexanoic acid PD-144723 CI 1008 (S+)-3-isobutyl GABA 1008 CI Pregabalin Lyrica PREGABALIN |
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