loading...| Preferred Name |
Mirtazapine |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass374ae25c_1fe3_4c1a_bf63_12a518dd4f8d |
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| Chinese |
米氮平 |
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| label |
Mirtazapine |
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| MESH_Definition |
A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders. |
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| NCIt_Definition |
A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors. |
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| prefLabel |
Mirtazapine |
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| Synonyms |
MIRTAZAPINE 61337-67-5 Remeron Remergil Mirtazapin Mirtazapinum Norset Mirtazapine-containing product Zispin 12341014b-Hexahydro-2-methylpyrazino(21-a)pyrido(23-c)benzazepine Mirtazapina Mepirzapine 6-Azamianserin Mirtazapine (substance) Product containing mirtazapine (medicinal product) 6 Azamianserin |
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| subClassOf |