loading...| Preferred Name |
Alprazolam |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass309ffa9d_b757_46ec_9f72_f92e4c6c7bfc |
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| Chinese |
阿普唑仑 |
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| label |
Alprazolam |
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| MESH_Definition |
A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238) |
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| NCIt_Definition |
A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) binding site on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and leads to a decrease in neuronal excitability. |
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| prefLabel |
Alprazolam |
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| Synonyms |
8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(43-a)(14)benzodiazepine 4H-(124)Triazolo(43-a)(14)benzodiazepine 8-chloro-1-methyl-6-phenyl- 28981-97-7 Alprazolam ALPRAZolam Alprazolam-containing product Xanax Product containing alprazolam (medicinal product) alprazolam Alprazolam (substance) Nu Alpraz Apo-Alpzar Alprazolan ALPRAZOLAM Nu-Alpraz Kalma D65MT U-31889 U31889 Alprox Cassadan Esparon Apo Alpraz Novo-Alprazol Tafil D-65MT Ralozam |
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