Preferred Name |
Ziprasidone |
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Synonyms |
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ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass19a14603_04a5_4ad8_94c7_2ba70ed4dbe6 |
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Chinese |
齐拉西酮 |
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NCIt_Definition |
A benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone also inhibits the synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors. |
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prefLabel |
Ziprasidone |
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Synonyms |
Ziprasidone-containing product ZIPRASIDONE ziprazidone Zeldox Product containing ziprasidone (medicinal product) Ziprasidona Ziprasidone (substance) 2H-Indol-2-one 5-(2-(4-(12-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-13-dihydro- 5-(2-(4-(3-benzisothiazolyl)piperazinyl)ethyl)-6-chloro-13-dihydro-2H-indol-2-one Ziprasidonum |
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subClassOf |