Zonisamide

http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass1304993a_389d_476e_800c_183f0b83c34e

对于患有遗传性（特发性全身性）癫痫的育龄期、有怀孕计划的女性患者，拉莫三嗪和左乙拉西坦是首选治疗方案，唑尼沙胺和托吡酯为二线治疗方案。 The experts were asked to rank the appropriateness of various antiseizure drugs or interventions as monotherapy in a healthy woman in her reproductive years with genetically mediated (idiopathic generalized) epilepsy who is not currently pregnant or trying to conceive but wishes to have a family someday. Lamotrigine and levetiracetam were the treatments of choice; zonisamide and topiramate were considered second-line options. Shih JJ, Whitlock JB, Chimato N, Vargas E, Karceski SC, Frank RD. Epilepsy treatment in adults and adolescents: Expert opinion, 2016. Epilepsy Behav. 2017 Apr;69:186-222. doi: 10.1016/j.yebeh.2016.11.018. Epub 2017 Feb 23. PMID: 28237319. 对于患有遗传性（特发性全身性）癫痫的计划怀孕并母乳喂养的女性患者，拉莫三嗪和左乙拉西坦是首选治疗方案，唑尼沙胺为二线治疗方案。 Lamotrigine and levetiracetam were the treatments of choice; zonisamide was considered second-line therapy. Shih JJ, Whitlock JB, Chimato N, Vargas E, Karceski SC, Frank RD. Epilepsy treatment in adults and adolescents: Expert opinion, 2016. Epilepsy Behav. 2017 Apr;69:186-222. doi: 10.1016/j.yebeh.2016.11.018. Epub 2017 Feb 23. PMID: 28237319. 对于患有局灶性癫痫的计划怀孕并母乳喂养的女性患者，奥卡西平为首选治疗方案，拉莫三嗪和左乙拉西坦也是治疗选择；卡马西平、拉考沙胺、艾司利卡西平和唑尼沙胺为二线选择。 Lamotrigine and levetiracetam were the treatments of choice, with oxcarbazepine considered first-line treatment. Carbamazepine, lacosamide, eslicarbazepine, and zonisamide were considered second-line options. Shih JJ, Whitlock JB, Chimato N, Vargas E, Karceski SC, Frank RD. Epilepsy treatment in adults and adolescents: Expert opinion, 2016. Epilepsy Behav. 2017 Apr;69:186-222. doi: 10.1016/j.yebeh.2016.11.018. Epub 2017 Feb 23. PMID: 28237319. 对于患有遗传性（特发性全身性）癫痫合并抑郁症（服用或未服用抗抑郁药）的女性患者，首选治疗方案为拉莫三嗪，左乙拉西坦为二线治疗方案。对于唑尼沙胺、丙戊酸盐、托吡酯和拉考沙胺的治疗尚未达成共识。 The experts were asked to rank the appropriateness of various antiseizure drugs or interventions as monotherapy in a woman with depression (who may or may not be on an antidepressant) with genetically mediated (idiopathic generalized) epilepsy. The treatment of choice was lamotrigine, while levetiracetam was considered second-line therapy. No consensus could be reached regarding treatment with zonisamide, valproate, topiramate, and lacosamide. Shih JJ, Whitlock JB, Chimato N, Vargas E, Karceski SC, Frank RD. Epilepsy treatment in adults and adolescents: Expert opinion, 2016. Epilepsy Behav. 2017 Apr;69:186-222. doi: 10.1016/j.yebeh.2016.11.018. Epub 2017 Feb 23. PMID: 28237319. 对于患有局灶性癫痫合并抑郁症（服用或未服用抗抑郁药）的女性患者，拉莫三嗪为首选治疗，奥卡西平和拉考沙胺也可作为一线治疗，卡马西平、艾司利卡西平、左乙拉西坦和唑尼沙胺为二线治疗。 The experts were asked to rank the appropriateness of various anti-seizure drugs or interventions as monotherapy in a woman with depression (who may or may not be on an antidepressant) with focal (symptomatic localization related) epilepsy. Lamotrigine was the treatment of choice, oxcarbazepine and lacosamide were considered first-line therapy, and carbamazepine, eslicarbazepine, levetiracetam, and zonisamide were considered second-line therapy.Shih JJ, Whitlock JB, Chimato N, Vargas E, Karceski SC, Frank RD. Epilepsy treatment in adults and adolescents: Expert opinion, 2016. Epilepsy Behav. 2017 Apr;69:186-222. doi: 10.1016/j.yebeh.2016.11.018. Epub 2017 Feb 23. PMID: 28237319.

唑尼沙胺

Zonisamide

A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.

A sulfonamide derivative with an anticonvulsant property. The exact mechanism of action remains to be elucidated. Zonisamide appears to block sodium and calcium channels, thereby stabilizing neuronal membranes and suppressing neuronal hyper-synchronization. Although zonisamide shows affinity for the gamma-aminobutyric acid (GABA)/benzodiazepine receptor ionophore complex, it does not potentiate the synaptic activity of GABA. In addition, this agent also facilitates both dopaminergic and serotonergic neurotransmission.

Zonisamide

zonisamide Zonisamide Zonisamide-containing product Product containing zonisamide (medicinal product) Zonisamide (substance) Excegram 3-Sulfamoylmethyl-12-benzisoxazole 3 Sulfamoylmethyl 12 benzisoxazole 12-Benzisoxazole-3-methanesulfonamide Zonisamidum Benzo[d]isoxazol-3-yl-methanesulfonamide ZONISAMIDE Zonegran 3-(Sulfamoylmethyl)-12-benzisoxazole Zonisamida

http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass759708f9_95b8_4278_b245_68ead2726509