loading...| Preferred Name |
Aldosterone-producing adenoma |
|
| Synonyms |
Aldosterone-producing adenoma (disorder) Aldosteronoma Conn adenoma Aldosterone-secreting adenoma Primary aldosteronism due to Conn adenoma |
|
| Definitions |
A type of primary hyperaldosteronism resulting from a benign neoplasm of the adrenal gland. The adrenal neoplasm increases production of aldosterone. Excess aldosterone causes the kidneys to retain more salt than usual resulting in increases in body fluid levels and blood pressure. The disease is caused by mutations in one of several genes. The most commonly mutated gene is KCNJ5, accounting for an estimated 40 percent of the neoplasms, followed by the CACNA1D and ATP1A1 genes. Changes in other genes cause a small percentage of cases with additional unidentified genes involved in the condition. The disease is generally not inherited but may arise from a mutation occurring after conception. |
|
| ID |
http://purl.bioontology.org/ontology/SNOMEDCT/768470007 |
|
| Active |
1 |
|
| altLabel |
Aldosterone-producing adenoma (disorder) Aldosteronoma Conn adenoma Aldosterone-secreting adenoma Primary aldosteronism due to Conn adenoma |
|
| CASE SIGNIFICANCE ID |
900000000000020002 900000000000448009 900000000000017005 |
|
| CTV3ID |
XV6Pj |
|
| cui |
C0009777 |
|
| definition |
A type of primary hyperaldosteronism resulting from a benign neoplasm of the adrenal gland. The adrenal neoplasm increases production of aldosterone. Excess aldosterone causes the kidneys to retain more salt than usual resulting in increases in body fluid levels and blood pressure. The disease is caused by mutations in one of several genes. The most commonly mutated gene is KCNJ5, accounting for an estimated 40 percent of the neoplasms, followed by the CACNA1D and ATP1A1 genes. Changes in other genes cause a small percentage of cases with additional unidentified genes involved in the condition. The disease is generally not inherited but may arise from a mutation occurring after conception. |
|
| DEFINITION STATUS ID |
900000000000074008 |
|
| Effective time |
20180731 |
|
| Has associated morphology | ||
| Has finding site | ||
| notation |
768470007 |
|
| prefLabel |
Aldosterone-producing adenoma |
|
| Subset member |
447562003~MAPRULE~TRUE 6011000124106~MAPGROUP~1 6011000124106~MAPGROUP~2 900000000000508004~ACCEPTABILITYID~900000000000549004 447562003~MAPGROUP~1 6011000124106~MAPTARGET~D35.00 447562003~CORRELATIONID~447561005 6011000124106~MAPCATEGORYID~447637006 900000000000509007~ACCEPTABILITYID~900000000000548007 900000000000508004~ACCEPTABILITYID~900000000000548007 900000000000497000~MAPTARGET~XV6Pj 447562003~MAPPRIORITY~1 447562003~MAPCATEGORYID~447637006 447562003~MAPADVICE~ALWAYS E26.0 6011000124106~MAPTARGET~E26.01 6011000124106~MAPADVICE~ALWAYS E26.01 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE 6011000124106~MAPADVICE~ALWAYS D35.00 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | CONSIDER LATERALITY SPECIFICATION 6011000124106~MAPPRIORITY~1 6011000124106~CORRELATIONID~447561005 6011000124106~MAPRULE~TRUE 900000000000509007~ACCEPTABILITYID~900000000000549004 447562003~MAPTARGET~E26.0 |
|
| tui |
T191 |
|
| Type ID |
900000000000003001 900000000000013009 |
|
| subClassOf |