Sepsis Ontology

Last uploaded: May 14, 2024
Preferred Name

Polymyxin B

Synonyms
ID

http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Polymyxin_B

definition

A mixture of the polypeptides polymyxins B1 and B2, both obtained from Bacillus polymyxa strains, with antimicrobial activity. Polymyxin B exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death.

label

Polymyxin B

prefixIRI

Polymyxin_B

prefLabel

Polymyxin B

reference

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61894

Synonyms

POLYMYXIN B Polymyxin B

subClassOf

http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Polymyxin_Antibiotic

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http://purl.bioontology.org/ontology/VANDF/4018594 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.641.780.750 RH-MESH LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000780525 PDQ LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018767 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/MESH/D011112 MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C61894 BERO LOOM
http://www.co-ode.org/ontologies/galen#PolymyxinB GALEN LOOM
http://purl.bioontology.org/ontology/ATC/S03AA03 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/8536 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/LP16319-3 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0032535 OCHV LOOM
http://purl.bioontology.org/ontology/SNMI/C-52270 SNMI LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007602 LOINC LOOM
http://purl.jp/bio/4/id/200906075598067747 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.345.566.780.750 RH-MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61894 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.477.750.750 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0012079 OMIT LOOM
http://purl.bioontology.org/ontology/ATC/S01AA18 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146910 NDFRT LOOM
http://purl.bioontology.org/ontology/RCD/x02Lu RCD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#9927 OCHV LOOM
https://go.drugbank.com/drugs/DB00781 MDM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.543.695.054.600.750 RH-MESH LOOM
http://purl.obolibrary.org/obo/ARO_3000454 ARO LOOM
http://purl.bioontology.org/ontology/ATC/A07AA05 ATC LOOM
http://purl.bioontology.org/ontology/ATC/S02AA11 ATC LOOM
http://purl.bioontology.org/ontology/ATC/J01XB02 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.050.600.750 RH-MESH LOOM
http://purl.obolibrary.org/obo/MESH_D011112 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_8309 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_8309 DRON LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011112 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372824005 SNOMEDCT LOOM