loading...| Preferred Name |
Interleukin-12 |
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| Synonyms |
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| ID |
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Interleukin-12 |
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| definition |
Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. |
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| label |
Interleukin-12 |
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| prefixIRI |
Interleukin-12 |
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| prefLabel |
Interleukin-12 |
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| reference | ||
| Synonyms |
Natural Killer Cell Stimulatory Factor Interleukin-12 Cytotoxic Lymphocyte Maturation Factor Interleukin 12 CLMF IL-12 IL-12 p70 IL-12p70 IL12 NKSF |
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| subClassOf |
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Interleukin http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Neonatal_Sepsis_Biomarker |