Preferred Name |
Pemetrexed |
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Synonyms |
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Definitions |
A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. |
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ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61614 |
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definition |
A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. |
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isDefinedBy | ||
label |
Pemetrexed |
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prefixIRI |
ncit:C61614 |
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prefLabel |
Pemetrexed |
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seeAlso |
EuroCAT Umbrella Protocol for NSCLC |
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subClassOf |
Create mapping