PMO Precision Medicine Ontology

Last uploaded: December 16, 2020
Preferred Name

DNA Repair

Synonyms
Definitions

"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]

ID

http://www.phoc.org.cn/pmo/class/PMO_00057351

Database_Cross_Reference

GO:0006281

Definition

"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]

Gene Annotation

RAD1(UniProtKB:O60671)

CGAS(UniProtKB:Q8N884)

SSRP1(UniProtKB:Q08945)

VCP(UniProtKB:P55072)

NONO(UniProtKB:Q15233)

ENDOV(UniProtKB:Q8N8Q3)

NOP53(UniProtKB:Q9NZM5)

MRE11(UniProtKB:P49959)

ERCC3(UniProtKB:P19447)

RUVBL1(UniProtKB:Q9Y265)

EXO1(UniProtKB:Q9UQ84)

CDK1(UniProtKB:P06493)

GADD45A(UniProtKB:P24522)

NSMCE3(UniProtKB:Q96MG7)

TOPBP1(UniProtKB:Q92547)

UBE2D3(UniProtKB:P61077)

UHRF1(UniProtKB:Q96T88)

KIF22(UniProtKB:Q14807)

RECQL4(UniProtKB:O94761)

DDB2(UniProtKB:Q92466)

EYA2(UniProtKB:O00167)

hCG_2039718(UniProtKB:K7EN88)

MSH6(UniProtKB:P52701)

ERCC4(UniProtKB:Q92889)

PARK7(UniProtKB:Q99497)

ZRANB3(UniProtKB:Q5FWF4)

MRNIP(UniProtKB:Q6NTE8)

PWWP3A(UniProtKB:Q2TAK8)

PDS5A(UniProtKB:Q29RF7)

FANCG(UniProtKB:O15287)

SLX4(UniProtKB:Q8IY92)

CSNK1E(UniProtKB:P49674)

EPC2(UniProtKB:Q52LR7)

RRM2B(UniProtKB:Q7LG56)

ATRIP(UniProtKB:Q8WXE1)

RPAIN(UniProtKB:Q86UA6)

ZMPSTE24(UniProtKB:O75844)

SHLD2(UniProtKB:Q86V20)

TDP1(UniProtKB:Q9NUW8)

BCCIP(UniProtKB:Q9P287)

FZR1(UniProtKB:Q9UM11)

RAD54L(UniProtKB:Q92698)

TAOK3(UniProtKB:Q9H2K8)

BLM(UniProtKB:P54132)

FOXM1(UniProtKB:Q08050)

SMG1(UniProtKB:Q96Q15)

FANCD2(UniProtKB:Q9BXW9)

POLG2(UniProtKB:Q9UHN1)

MUS81(UniProtKB:Q96NY9)

ASF1A(UniProtKB:Q9Y294)

PNKP(UniProtKB:Q96T60)

CHRNA4(UniProtKB:P43681)

EID3(UniProtKB:Q8N140)

ZBTB1(UniProtKB:Q9Y2K1)

OTUB1(UniProtKB:Q96FW1)

BRCC3(UniProtKB:P46736)

UVRAG(UniProtKB:Q9P2Y5)

FAN1(UniProtKB:Q9Y2M0)

GTF2H1(UniProtKB:P32780)

INTS3(UniProtKB:Q68E01)

USP45(UniProtKB:Q70EL2)

NFRKB(UniProtKB:Q6P4R8)

MSH3(UniProtKB:P20585)

EYA4(UniProtKB:O95677)

UBE2U(UniProtKB:Q5VVX9)

RAD9A(UniProtKB:Q99638)

PARP1(UniProtKB:P09874)

ATR(UniProtKB:Q13535)

PARP2(UniProtKB:Q9UGN5)

NPM1(UniProtKB:P06748)

RAD51B(UniProtKB:O15315)

TRIP12(UniProtKB:Q14669)

USP51(UniProtKB:Q70EK9)

PSME4(UniProtKB:Q14997)

HELB(UniProtKB:Q8NG08)

CHAF1A(UniProtKB:Q13111)

FANCA(UniProtKB:O15360)

CEP164(UniProtKB:Q9UPV0)

NCOA6(UniProtKB:Q14686)

HINFP(UniProtKB:Q9BQA5)

RPA1(UniProtKB:P27694)

TAOK1(UniProtKB:Q7L7X3)

CDK9(UniProtKB:P50750)

RECQL(UniProtKB:P46063)

HDAC10(UniProtKB:Q969S8)

PARPBP(UniProtKB:Q9NWS1)

UBQLN4(UniProtKB:Q9NRR5)

SMC3(UniProtKB:Q9UQE7)

DDB1(UniProtKB:Q16531)

MSH2(UniProtKB:P43246)

FEN1(UniProtKB:P39748)

WRAP53(UniProtKB:Q9BUR4)

MEN1(UniProtKB:O00255)

FANCC(UniProtKB:Q00597)

BACH1(UniProtKB:O14867)

INO80(UniProtKB:Q9ULG1)

RBM14(UniProtKB:Q96PK6)

TRRAP(UniProtKB:Q9Y4A5)

POLE2(UniProtKB:P56282)

PAGR1(UniProtKB:Q9BTK6)

POLK(UniProtKB:Q9UBT6)

LIG1(UniProtKB:P18858)

UBE2T(UniProtKB:Q9NPD8)

MCRS1(UniProtKB:Q96EZ8)

NUDT1(UniProtKB:P36639)

CDC14B(UniProtKB:O60729)

INIP(UniProtKB:Q9NRY2)

IGHMBP2(UniProtKB:P38935)

USP3(UniProtKB:Q9Y6I4)

RMI2(UniProtKB:Q96E14)

UNG(UniProtKB:P13051)

XRCC3(UniProtKB:O43542)

RAD9B(UniProtKB:Q6WBX8)

JMY(UniProtKB:Q8N9B5)

MGMT(UniProtKB:P16455)

SHPRH(UniProtKB:Q149N8)

TIMELESS(UniProtKB:Q9UNS1)

CLSPN(UniProtKB:Q9HAW4)

TTC5(UniProtKB:Q8N0Z6)

GTF2H3(UniProtKB:Q13889)

INO80C(UniProtKB:Q6PI98)

RTEL1(UniProtKB:Q9NZ71)

CHEK1(UniProtKB:O14757)

TRIM28(UniProtKB:Q13263)

RAD51D(UniProtKB:O75771)

WDHD1(UniProtKB:O75717)

CENPS(UniProtKB:Q8N2Z9)

RTEL1-TNFRSF6B(UniProtKB:F6WH68)

RPA2(UniProtKB:P15927)

ALKBH1(UniProtKB:Q13686)

BTG2(UniProtKB:P78543)

FANCL(UniProtKB:Q9NW38)

UBR5(UniProtKB:O95071)

ACTL6A(UniProtKB:O96019)

CDC5L(UniProtKB:Q99459)

FBH1(UniProtKB:Q8NFZ0)

NSMCE4A(UniProtKB:Q9NXX6)

CINP(UniProtKB:Q9BW66)

APEX1(UniProtKB:P27695)

RAD50(UniProtKB:Q92878)

NABP1(UniProtKB:Q96AH0)

SUMO1(UniProtKB:P63165)

MUTYH(UniProtKB:Q9UIF7)

SMARCAL1(UniProtKB:Q9NZC9)

A0A1W2PQ90(UniProtKB:A0A1W2PQ90)

RAD51C(UniProtKB:O43502)

RFC5(UniProtKB:P40937)

POLD1(UniProtKB:P28340)

UBE2B(UniProtKB:P63146)

POLH(UniProtKB:Q9Y253)

CHD1L(UniProtKB:Q86WJ1)

SLX1A(UniProtKB:Q9BQ83)

RAD51(UniProtKB:Q06609)

UCHL5(UniProtKB:Q9Y5K5)

KIN(UniProtKB:O60870)

DMAP1(UniProtKB:Q9NPF5)

PPP5C(UniProtKB:P53041)

EMSY(UniProtKB:Q7Z589)

RAD17(UniProtKB:O75943)

RPS3(UniProtKB:P23396)

UBE2A(UniProtKB:P49459)

SLF2(UniProtKB:Q8IX21)

SMC1A(UniProtKB:Q14683)

INO80B(UniProtKB:Q9C086)

INO80D(UniProtKB:Q53TQ3)

TICRR(UniProtKB:Q7Z2Z1)

PTTG1(UniProtKB:O95997)

TEX15(UniProtKB:Q9BXT5)

ERCC1(UniProtKB:P07992)

XRCC2(UniProtKB:O43543)

TREX1(UniProtKB:Q9NSU2)

BOD1L1(UniProtKB:Q8NFC6)

SHLD1(UniProtKB:Q8IYI0)

WRN(UniProtKB:Q14191)

PIF1(UniProtKB:Q9H611)

POLI(UniProtKB:Q9UNA4)

HUS1(UniProtKB:O60921)

POLB(UniProtKB:P06746)

POLA1(UniProtKB:P09884)

RBM17(UniProtKB:Q96I25)

CHAF1B(UniProtKB:Q13112)

RAD51AP1(UniProtKB:Q96B01)

ETAA1(UniProtKB:Q9NY74)

ASTE1(UniProtKB:Q2TB18)

PARP3(UniProtKB:Q9Y6F1)

PDS5B(UniProtKB:Q9NTI5)

ATRX(UniProtKB:P46100)

UBE2W(UniProtKB:Q96B02)

NABP2(UniProtKB:Q9BQ15)

ALKBH3(UniProtKB:Q96Q83)

RNF113A(UniProtKB:O15541)

RAD18(UniProtKB:Q9NS91)

XPA(UniProtKB:P23025)

RUVBL2(UniProtKB:Q9Y230)

USP28(UniProtKB:Q96RU2)

HSF1(UniProtKB:Q00613)

TREX2(UniProtKB:Q9BQ50)

SHLD3(UniProtKB:Q6ZNX1)

SMC6(UniProtKB:Q96SB8)

ADPRHL2(UniProtKB:Q9NX46)

MMS19(UniProtKB:Q96T76)

STUB1(UniProtKB:Q9UNE7)

EEPD1(UniProtKB:Q7L9B9)

DDX11(UniProtKB:Q96FC9)

RBBP8(UniProtKB:Q99708)

TFPT(UniProtKB:P0C1Z6)

MORF4L2(UniProtKB:Q15014)

GTF2H4(UniProtKB:Q92759)

RPA4(UniProtKB:Q13156)

RECQL5(UniProtKB:O94762)

POLQ(UniProtKB:O75417)

FH(UniProtKB:P07954)

CDK2(UniProtKB:P24941)

SUPT16H(UniProtKB:Q9Y5B9)

XPC(UniProtKB:Q01831)

UPF1(UniProtKB:Q92900)

ANKLE1(UniProtKB:Q8NAG6)

SLF1(UniProtKB:Q9BQI6)

PARP4(UniProtKB:Q9UKK3)

FBXO6(UniProtKB:Q9NRD1)

MBD4(UniProtKB:O95243)

INO80E(UniProtKB:Q8NBZ0)

label

DNA Repair

MCID

MC04769356

PMOID

PMO:00057351

prefixIRI

pmo:PMO_00057351

prefLabel

DNA Repair

Tree Number

T10.1.14.20.3.5.3.26

T10.1.14.3.42.3.26

T10.1.14.3.12.11.5.3.26

T10.1.29.29.42.3.26

T10.1.14.8.5.2.5.3.26

T10.1.29.29.22.2.5.3.26

T10.1.13.8.2.24.8

T10.1.14.3.22.2.5.3.26

T10.1.14.13.44.11.3.26

T10.1.29.52.2.24.8

T10.1.29.29.12.11.5.3.26

T10.1.14.3.6.25.5.3.26

T10.1.14.13.44.14.3.26

T10.1.13.12.27.24.8

T10.1.29.29.6.25.5.3.26

T10.1.14.13.34.64.5.3.26

subClassOf

http://www.phoc.org.cn/pmo/class/PMO_00067477

http://www.phoc.org.cn/pmo/class/PMO_00057288

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/GO_0006281 FYPO LOOM
http://purl.obolibrary.org/obo/GO_0006281 GO-PLUS LOOM
http://purl.obolibrary.org/obo/GO_0006281 GO LOOM
http://purl.obolibrary.org/obo/GO_0006281 ZP LOOM
http://purl.obolibrary.org/obo/GO_0006281 DPO LOOM
http://purl.obolibrary.org/obo/GO_0006281 EFO LOOM
http://purl.obolibrary.org/obo/GO_0006281 FYPO LOOM
http://purl.obolibrary.org/obo/GO_0006281 HOIP LOOM
http://purl.obolibrary.org/obo/GO_0006281 OBA LOOM
http://purl.obolibrary.org/obo/NCIT_C16513 BERO LOOM
http://purl.obolibrary.org/obo/IEV_0000872 PTS LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0012899 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D004260 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#G02.149.115.219 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/2102-8256 CRISP LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16513 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#G02.111.087.219 RH-MESH LOOM
http://purl.org/obo/owl/GO#GO_0006281 BIOMODELS LOOM
http://purl.jp/bio/4/id/200906046713972181 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/65113001 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/GMM_28.2 GMM LOOM
http://purl.obolibrary.org/obo/GO_0006281 NIGO LOOM
http://purl.obolibrary.org/obo/GO_0006281 RBO LOOM
http://purl.obolibrary.org/obo/GO_0006281 GO-EXT LOOM
http://purl.obolibrary.org/obo/GO_0006281 PHAGE LOOM
http://purl.obolibrary.org/obo/GO_0006281 BAO LOOM
http://purl.obolibrary.org/obo/GO_0006281 DPO LOOM
http://purl.obolibrary.org/obo/GO_0006281 BERO LOOM
http://purl.obolibrary.org/obo/GO_0006281 TXPO LOOM
http://purl.obolibrary.org/obo/GO_0006281 UPHENO LOOM
http://purl.obolibrary.org/obo/GO_0006281 FTC LOOM
http://purl.obolibrary.org/obo/GO_0006281 NIFSTD LOOM
http://purl.obolibrary.org/obo/GO_0006281 KTAO LOOM
http://purl.obolibrary.org/obo/GO_0006281 REGN_GO LOOM
http://localhost/plosthes.2017-1#5436 PLOSTHES LOOM
http://purl.obolibrary.org/obo/OMIT_0005517 OMIT LOOM
http://purl.obolibrary.org/obo/MESH_D004260 BERO LOOM
http://www.projecthalo.com/aura#DNA-Repair AURA LOOM
urn:agi-folder:dna_repair BPT LOOM
http://purl.bioontology.org/ontology/SNMI/F-E2660 SNMI LOOM
http://purl.obolibrary.org/obo/HINO_0016411 HINO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004260 RH-MESH LOOM
http://doe-generated-ontology.com/OntoAD#C0012899 ONTOAD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#G05.355.195 RH-MESH LOOM