loading...| Preferred Name |
Doxazosin |
|
| Synonyms |
2-[4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine Doxazosin 1-(4-Amino-6,7-Dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin 1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazin doxazosinum doxazosin doxazosina doxazosine |
|
| Definitions |
A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_4708 |
|
| charge |
0 |
|
| database_cross_reference |
Wikipedia:Doxazosin KEGG:D07874 CAS:74191-85-8 Beilstein:731849 PMID:18559700 LINCS:LSM-4335 Reaxys:731849 Drug_Central:954 PMID:17171413 DrugBank:DB00590 KEGG:C06970 Patent:US4188390 HMDB:HMDB0014728 Patent:DE2847623 |
|
| formula |
C23H25N5O5 |
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_35620 http://purl.obolibrary.org/obo/CHEBI_37890 |
|
| has_exact_synonym |
2-[4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine Doxazosin |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
1-(4-Amino-6,7-Dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin 1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazin doxazosinum doxazosin doxazosina doxazosine |
|
| has_RxCUI |
49276 |
|
| id |
CHEBI:4708 |
|
| in_subset | ||
| inchi |
InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26) |
|
| inchikey |
RUZYUOTYCVRMRZ-UHFFFAOYSA-N |
|
| label |
Doxazosin doxazosin |
|
| mass |
451.47510 |
|
| monoisotopicmass |
451.18557 |
|
| notation |
CHEBI:4708 |
|
| prefixIRI |
CHEBI:4708 |
|
| prefLabel |
Doxazosin |
|
| smiles |
COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2ccccc2O1 |
|
| textual definition |
A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure. |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_46844 http://purl.obolibrary.org/obo/CHEBI_33860 http://purl.obolibrary.org/obo/CHEBI_38530 http://purl.obolibrary.org/obo/CHEBI_46848 |