loading...| Preferred Name |
Lovastatin |
|
| Synonyms |
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate LOVASTATIN Lovastatin lovastatin 6alpha-methylcompactin (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate 2beta,6alpha-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone MK-803 ML-530B Mevacor Mevinolin |
|
| Definitions |
A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom). |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_40303 |
|
| charge |
0 |
|
| database_cross_reference |
PDBeChem:803 CAS:75330-75-5 DrugBank:DB00227 KEGG:C07074 LINCS:LSM-2189 Drug_Central:1612 PMID:24093797 Patent:CN103172602 Patent:WO2013090461 PMID:11389707 Reaxys:4720754 PMID:7720768 PMID:11483865 KNApSAcK:C00000547 Beilstein:3631989 PMID:11375168 PMID:18642339 KEGG:D00359 HMDB:HMDB0014372 Wikipedia:Lovastatin |
|
| formula |
C24H36O5 |
|
| has functional parent | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_35821 |
|
| has_alternative_id |
CHEBI:40299 CHEBI:6544 |
|
| has_exact_synonym |
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate LOVASTATIN Lovastatin lovastatin |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
6alpha-methylcompactin (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate 2beta,6alpha-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone MK-803 ML-530B Mevacor Mevinolin |
|
| has_RxCUI |
6472 |
|
| id |
CHEBI:40303 |
|
| in_subset | ||
| inchi |
InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1 |
|
| inchikey |
PCZOHLXUXFIOCF-BXMDZJJMSA-N |
|
| label |
Lovastatin lovastatin |
|
| mass |
404.53964 |
|
| monoisotopicmass |
404.25627 |
|
| notation |
CHEBI:40303 |
|
| prefixIRI |
CHEBI:40303 |
|
| prefLabel |
Lovastatin |
|
| smiles |
[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC |
|
| textual definition |
A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom). |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_35748 http://purl.obolibrary.org/obo/CHEBI_87632 http://purl.obolibrary.org/obo/CHEBI_142348 |