loading...| Preferred Name |
parecoxib sodium |
|
| Synonyms |
Dynastat |
|
| Definitions |
A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon intravenous or intramuscular administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation. |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000753381 |
|
| altLabel |
Dynastat propanamide, N-((4-(5-methyl-3-phenyl-4- isoxazolyl)phenyl)sulfonyl)-, sodium salt |
|
| CAS Registry |
198470-85-8 |
|
| cui |
C0915144 C1174775 |
|
| DATE FIRST PUBLISHED |
2013-10-17 |
|
| Date last modified |
2013-10-22 |
|
| definition |
A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon intravenous or intramuscular administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation. |
|
| LT |
TRD |
|
| notation |
CDR0000753381 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
parecoxib sodium |
|
| tui |
T109 T121 |