loading...| Preferred Name |
fluvoxamine maleate |
|
| Synonyms |
fluoxamine |
|
| Definitions |
The maleate salt form of fluvoxamine, a 2-aminoethyl oxime ether of aralkylketones, with antidepressant, antiobsessive-compulsive, and antibulimic activities. Fluvoxamine blocks serotonin reuptake by inhibiting the serotonin reuptake pump of the presynaptic neuronal membrane leading to an increase of serotonin levels within the synaptic cleft. This results in facilitated serotonergic transmission and decreased serotonin turnover leading to antidepressant and antiobsessive-compulsive effects. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29063" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29063" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000735770 |
|
| altLabel |
fluoxamine Luvox |
|
| CAS Registry |
61718-82-9 |
|
| cui |
C0700473 C0085228 C0086307 |
|
| DATE FIRST PUBLISHED |
2012-06-20 |
|
| Date last modified |
2012-06-20 |
|
| definition |
The maleate salt form of fluvoxamine, a 2-aminoethyl oxime ether of aralkylketones, with antidepressant, antiobsessive-compulsive, and antibulimic activities. Fluvoxamine blocks serotonin reuptake by inhibiting the serotonin reuptake pump of the presynaptic neuronal membrane leading to an increase of serotonin levels within the synaptic cleft. This results in facilitated serotonergic transmission and decreased serotonin turnover leading to antidepressant and antiobsessive-compulsive effects. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29063" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29063" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C29063 |
|
| notation |
CDR0000735770 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
fluvoxamine maleate |
|
| tui |
T109 T121 |