loading...| Preferred Name |
sofosbuvir |
|
| Synonyms |
nucleotide NS5B inhibitor GS-7977 GS-7977 PSI-7977 |
|
| Definitions |
An orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase inhibitor with potential HCV inhibiting activity. Upon oral administration, sofosbuvir is metabolized to 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine-5'-monophosphate, which is then converted into the active triphosphate nucleotide that inhibits the NS5B polymerase, thereby preventing viral replication. The HCV NS5B protein, an RNA-dependent RNA polymerase, is essential for the replication of the viral HCV RNA genome. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C101263" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C101263" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000729636 |
|
| altLabel |
nucleotide NS5B inhibitor GS-7977 GS-7977 PSI-7977 |
|
| cui |
C3530149 C2976304 C2976303 |
|
| DATE FIRST PUBLISHED |
2012-03-23 |
|
| Date last modified |
2012-08-16 |
|
| definition |
An orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase inhibitor with potential HCV inhibiting activity. Upon oral administration, sofosbuvir is metabolized to 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine-5'-monophosphate, which is then converted into the active triphosphate nucleotide that inhibits the NS5B polymerase, thereby preventing viral replication. The HCV NS5B protein, an RNA-dependent RNA polymerase, is essential for the replication of the viral HCV RNA genome. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C101263" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C101263" NCI Thesaurus) |
|
| NCI ID |
C101263 |
|
| notation |
CDR0000729636 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
sofosbuvir |
|
| tui |
T109 T114 T121 |