loading...| Preferred Name |
doxepin hydrochloride |
|
| Synonyms |
Sinequan |
|
| Definitions |
A dibenzoxepin derivative and tricyclic antidepressant with antipruritic and sedative activities. Doxepin blocks the reuptake of norepinephrine and serotonin into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their action leading to sedative effects. Doxepin also has antagonistic effects on histamine (H1 and H2), 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is the result mediated through inhibition of histamine receptors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29006" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29006" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000681082 |
|
| altLabel |
Sinequan Adapin |
|
| CAS Registry |
1229-29-4 |
|
| cui |
C0728757 C0728756 C0700535 |
|
| DATE FIRST PUBLISHED |
2010-06-29 |
|
| Date last modified |
2017-12-18 |
|
| definition |
A dibenzoxepin derivative and tricyclic antidepressant with antipruritic and sedative activities. Doxepin blocks the reuptake of norepinephrine and serotonin into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their action leading to sedative effects. Doxepin also has antagonistic effects on histamine (H1 and H2), 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is the result mediated through inhibition of histamine receptors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29006" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29006" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C29006 |
|
| notation |
CDR0000681082 |
|
| NSC Code |
108160 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
doxepin hydrochloride |
|
| tui |
T109 T121 |