loading...| Preferred Name |
sevoflurane |
|
| Synonyms |
Ultane |
|
| Definitions |
A fluorinated isopropyl ether with general anesthetic activity. Although the mechanism of action has not been fully elucidated, sevoflurane may interfere with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter ionic conductance following receptor activation by a neurotransmitter. This agent may also interact directly with the lipid matrix of neuronal membranes, thereby affecting gating properties of ion channels. In addition, sevoflurane may activate gamma-aminobutyric acid (GABA) receptors, hyperpolarizing cell membranes and resulting in a general anesthetic effect, a decrease in myocardial contractility and mean arterial pressure, and an increased respiratory rate. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47717" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47717" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000524061 |
|
| altLabel |
Ultane 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane Ether, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl- |
|
| CAS Registry |
28523-86-6 |
|
| cui |
C0074414 C0724047 |
|
| DATE FIRST PUBLISHED |
2006-12-01 |
|
| Date last modified |
2009-01-16 |
|
| definition |
A fluorinated isopropyl ether with general anesthetic activity. Although the mechanism of action has not been fully elucidated, sevoflurane may interfere with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter ionic conductance following receptor activation by a neurotransmitter. This agent may also interact directly with the lipid matrix of neuronal membranes, thereby affecting gating properties of ion channels. In addition, sevoflurane may activate gamma-aminobutyric acid (GABA) receptors, hyperpolarizing cell membranes and resulting in a general anesthetic effect, a decrease in myocardial contractility and mean arterial pressure, and an increased respiratory rate. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47717" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47717" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47717 |
|
| notation |
CDR0000524061 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
sevoflurane |
|
| tui |
T109 T121 |