loading...| Preferred Name |
amantadine hydrochloride |
|
| Synonyms |
Symadine |
|
| Definitions |
The hydrochloride salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28818" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28818" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000471831 |
|
| altLabel |
Symadine Symmetrel Amantadine HCl |
|
| cui |
C0723562 C0026055 C0936072 |
|
| DATE FIRST PUBLISHED |
2006-03-07 |
|
| Date last modified |
2006-07-20 |
|
| definition |
The hydrochloride salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28818" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28818" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C28818 |
|
| notation |
CDR0000471831 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
amantadine hydrochloride |
|
| tui |
T109 T121 |