loading...| Preferred Name |
alpha-lipoic acid |
|
| Synonyms |
thioctic acid |
|
| Definitions |
A naturally occurring micronutrient, synthesized in small amounts by plants and animals (including humans), with antioxidant and potential chemopreventive activities. Alpha-lipoic acid acts as a free radical scavenger and assists in repairing oxidative damage and regenerates endogenous antioxidants, including vitamins C and E and glutathione. This agent also promotes glutathione synthesis. In addition, alpha-lipoic acid exerts metal chelating capacities and functions as a cofactor in various mitochondrial enzyme complexes involved in the decarboxylation of alpha-keto acids. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61595" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61595" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000440740 |
|
| altLabel |
thioctic acid |
|
| cui |
C0023791 |
|
| DATE FIRST PUBLISHED |
2005-07-15 |
|
| Date last modified |
2010-03-16 |
|
| definition |
A naturally occurring micronutrient, synthesized in small amounts by plants and animals (including humans), with antioxidant and potential chemopreventive activities. Alpha-lipoic acid acts as a free radical scavenger and assists in repairing oxidative damage and regenerates endogenous antioxidants, including vitamins C and E and glutathione. This agent also promotes glutathione synthesis. In addition, alpha-lipoic acid exerts metal chelating capacities and functions as a cofactor in various mitochondrial enzyme complexes involved in the decarboxylation of alpha-keto acids. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61595" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61595" NCI Thesaurus) |
|
| NCI ID |
C61595 |
|
| notation |
CDR0000440740 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
alpha-lipoic acid |
|
| tui |
T109 T127 T121 |