Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

pravastatin sodium

Synonyms

PRAV

Definitions

The sodium salt of pravastatin with cholesterol-lowering and potential antineoplastic activities. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. In addition, pravastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cells; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29375" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29375" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000424450

altLabel

PRAV

Pravachol

CAS Registry

81131-70-6

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000424451

cui

C0700763

C0085542

C0700474

DATE FIRST PUBLISHED

2005-03-24

Date last modified

2017-12-13

definition

The sodium salt of pravastatin with cholesterol-lowering and potential antineoplastic activities. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. In addition, pravastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cells; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29375" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29375" NCI Thesaurus)

LT

TRD

NCI ID

C29375

notation

CDR0000424450

ORIG STY

Drug/agent

prefLabel

pravastatin sodium

tui

T109

T121

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http://purl.bioontology.org/ontology/NDFRT/N0000179608 NDFRT CUI
http://purl.bioontology.org/ontology/RXNORM/203144 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/203144 RXNORM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29375 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29375 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/96306007 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/96306007 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148255 NDFRT CUI
http://purl.bioontology.org/ontology/LNC/LP171630-9 LOINC CUI
http://sbmi.uth.tmc.edu/ontology/ochv#C0700474 OCHV LOOM
http://purl.bioontology.org/ontology/UATC/C10AA03 ATC CUI
http://purl.obolibrary.org/obo/CHEBI_8361 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8361 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8361 CHEBI LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148190 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148190 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4020369 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4020369 VANDF LOOM
http://purl.bioontology.org/ontology/NDDF/003606 NDDF CUI
http://purl.bioontology.org/ontology/VANDF/4020548 VANDF CUI
http://purl.bioontology.org/ontology/RCD/x01R3 RCD CUI
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148190 OCVDAE LOOM
http://www.co-ode.org/ontologies/galen#PravastatinSodium GALEN LOOM
http://purl.bioontology.org/ontology/SCTSPA/373566006 SCTSPA CUI
http://stirdf.jst.go.jp/id/200907011445726364 IOBC LOOM
http://purl.jp/bio/4/id/200906050743253101 IOBC LOOM
http://purl.bioontology.org/ontology/CSP/1991-2079 CRISP CUI
http://purl.bioontology.org/ontology/CSP/1991-2079 CRISP CUI
http://purl.bioontology.org/ontology/SNOMEDCT/373566006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNMI/C-80821 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-80821 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/96305006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/96305006 SCTSPA CUI
http://purl.bioontology.org/ontology/MESH/D017035 MESH CUI
http://purl.bioontology.org/ontology/MESH/D017035 MESH CUI
http://purl.bioontology.org/ontology/MESH/D017035 MESH CUI
http://purl.bioontology.org/ontology/RCD/x02hc RCD CUI
http://purl.bioontology.org/ontology/CSP/0658-5374 CRISP CUI
http://purl.bioontology.org/ontology/CSP/0658-5374 CRISP CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007054 NDFRT CUI
http://purl.bioontology.org/ontology/MSHFRE/D017035 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D017035 MSHFRE CUI
http://purl.bioontology.org/ontology/SCTSPA/96306007 SCTSPA CUI
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004006 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004006 DMTO LOOM
http://purl.bioontology.org/ontology/RXNORM/42463 RXNORM CUI
http://purl.bioontology.org/ontology/NDDF/003607 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/003607 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/203333 RXNORM CUI
http://purl.bioontology.org/ontology/SNMI/C-80820 SNMI CUI